The extracellular matrix (ECM)
The extracellular matrix (ECM) acts as the "soil" for cell growth. It plays a vital role in maintaining tissue structure, regulating cellular behaviors and transmitting cellular signals. In 2025, a new review published in the journal Cell listed changes in the extracellular matrix as the 13th hallmark of aging.
Hyaluronic acid (HA) is a core component of the extracellular matrix. Leveraging precision fermentation technology based on synthetic biology, Bloomage Biotech produces hyaluronic acid with various molecular weights. Different molecular weights of HA transmit distinct cellular signals, regulate cell differentiation, relieve inflammation and promote tissue repair.
Cell Communication
Cell communication serves as the "social network" of cells. It is essential for maintaining tissue homeostasis and coordinating physiological functions. Disorders in cell communication will impair the function of local tissues and may even affect the aging process of the whole body via systemic effects.
Bloomage Biotech has developed a series of ingredients for cellular metabolism and signal regulation. Based on in-depth understanding of cell behavior modulation, we have also developed serum-free cell culture media, enabling the high-activity and controllable culture of mesenchymal stem cells and other cell types.
Cells
Cells are the fundamental units of life. Abnormalities in various intracellular functions are the most direct and core manifestations of cellular senescence. Cellular senescence refers not merely to cell division arrest, but more importantly, to the disorder and changes of intracellular functions.
Bloomage Biotech develops active ingredients that target mitochondria and gene expression. By regulating the expression of specific genes and boosting cellular energy, these ingredients directly slow down cellular senescence. We have established 3D skin models that simulate skin conditions such as wound healing, senescence and glycation. Serving as highly efficient efficacy testing platforms, these models fully replicate the multi-layer structure of human skin for the evaluation of bioactive substances.
