When the intestinal barrier-including the gut microbiota and intestinal villi-is compromised, this leads to increased intestinal permeability, enabling bacterial endotoxins such as lipopolysaccharide (LPS) to translocate into the bloodstream, triggering chronic inflammation and disrupting metabolic homeostasis, including gut-liver and gut-insulin axis function, leading to insulin resistance and appetite dysregulation, among other metabolic disturbances, ultimately resulting in excessive adipose accumulation and systemic metabolic dysfunction, creating a vicious cycle of obesity.
We have introduced PMW (Probiotics, M-Traditional Chinese Medicine, W-Whole grains) super staple foods-a dietary approach specifically designed for Chinese consumers. The PMW approach integrates probiotics, traditional Chinese medicine-derived food ingredients, and whole grains. This approach aims to support healthy weight management by regulating intestinal health and improving intestinal axis function. The safety of the PMW approach has been validated in large-scale human studies, and is tailored to Chinese dietary preferences for sustainable adherence.
